Spravato®

What Is Spravato®?

Spravato® is a prescription nasal spray that contains esketamine, a form of ketamine. It is used in combination with an oral antidepressant and is administered under the supervision of a certified healthcare provider in a medical setting.

Unlike most antidepressants that take weeks to take effect, Spravato® works on different brain receptors and may provide rapid relief from symptoms of depression—sometimes within hours or days.

Who is a Spravato Candidate?

Spravato® is approved for adults with:

  • Treatment-Resistant Depression (TRD): You’ve tried at least two different antidepressant medications without success.
  • Major Depressive Disorder (MDD) with Suicidal Ideation or Behavior: You are experiencing severe depressive symptoms and need rapid intervention.

Please note, a thorough psychiatric evaluation is required to determine if Spravato® is the right fit for your condition and overall health. We will provide this to all patients prior to beginning treatment.

How Is Spravato® Different from Other Treatments?

  • Rapid Relief: Many patients report symptom improvement within hours to days.
  • Neuroplasticity Effects: Esketamine may help restore healthy brain function by forming new neural connections.
  • Used with Traditional Meds: It works alongside—not instead of—your oral antidepressants.

What Are the Side Effects?

Common side effects may include:

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    Dizziness

    Nausea

    Disassociation 

    Increased blood pressure

    Sleepiness or sedation

     These effects usually wear off shortly after treatment, and you’ll be monitored throughout the process

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    How Does the Treatment Work?

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      1. In-Clinic Administration: Spravato® is self-administered as a nasal spray, but only in a certified clinic under provider supervision.

      2. Monitoring Period: You’ll be monitored on-site for about 2 hours after each session to ensure your safety and observe any side effects.

      3. Treatment Schedule:
      • Weeks 1–4: Two treatments per week
      • Weeks 5–8: One treatment per week
      • Week 9 and onward: Maintenance treatments as needed

      *Please note, your treatment plan may be adjusted based on your response and goals.

      Why Choose Us for Spravato®?


      Peace of Mind offers:

      • Certified treatment provider under REMS (Risk Evaluation and Mitigation Strategy)
      • Personalized care in a private, safe environment
      • Collaborative approach with your primary psychiatrist or therapist
      • Ongoing monitoring and support throughout your treatment